Modern methods in stereoselective aldol reactions wiley. Propionate aldol reaction acetate aldol reaction two new stereocenters a single new stereocenter four stereoisomers two stereoisomers scheme 1. Heterocycles in natural product synthesis 2011 isbn. Enantioselective aldol reactions with fluoroacetate would enable access to numerous fluorinated analogues of therapeutically important compounds but. The selective formation of bondings between molecules is one of the major challenges in organic chemistry, and the so. Article in angewandte chemie 12622 may 2014 with 19 reads.
Modern methods in stereoselective aldol reactions ebook. Lee modern methods in stereoselective aldol reactions por disponible en rakuten kobo. The aldol reaction is one of the most powerful and versatile methods in polyketide synthesis. Nevertheless, the subtle directing effects remain very often obscure and impede complex natural. Download it once and read it on your kindle device, pc, phones or tablets. The selective formation of bondings between molecules is one of the major. Modern methods in stereoselective aldol reactions 1. The origin of higher reactivity in the wateraccelerated asymmetric aldol reactions with our designed primaryamine organocatalyst was elucidated by both computational and experimental methods. Use features like bookmarks, note taking and highlighting while reading modern methods in stereoselective aldol reactions. Modern methods in stereoselective aldol reactions, first edition.
The selective formation of bondings between molecules is one of the major challenges in organic chemistry, and the socalled aldol reaction is one of the most important for this purpose. Ward and others published modern methods in stereoselective aldol reactions find, read and cite all the research you need on researchgate. Escrich, shoulei wang, sonia sayalero and miquel a. A novel and simple organocatalyst derived from proline was designed, synthesized and tested for its catalytic potential in a direct asymmetric aldol reaction between 4nitrobenzaldehyde and. Modern aldol reactions, this ready reference provides a systematic overview of methodologies for installing a required configuration during an aldol addition step, but shifts the focus so as to cover the latest developments. Aldol reactions of acetaldehyde mediated by a dual catalytic system operating under site isolation, chemistry a european journal, 20, 41, 8993, 2014.